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Description
The support plays a critical role in several ways in the performance of the column. First, it governs the efficiency of the column (narrowness of peaks). The structure of the support, and the manner in which it is coated, both contribute to the efficiency. Secondly, the wrong choice of support can interact with the sample to cause the chromatographic peaks to tail, i.e., they can be highly asymmetrical and consequently difficult or impossible to measure. Ideally, the support should not interact with the sample but, in practice, this does occur. By careful selection of the support and conditions, one can minimize this problem.
1 A large surface area
2 High chemical inertness
3 High thermal stability
4 Uniform particles
5 High mechanical strength
1 A large surface area
2 High chemical inertness
3 High thermal stability
4 Uniform particles
5 High mechanical strength
Review
Review
